منابع مشابه
Motility without invasion
P eaks and valleys in protein translation prepare one set of immune cells for duty, according to fi ndings from Lelouard et al. With the ebb and fl ow of translation, antigenpresenting dendritic cells (DCs) adjust the origin of their antigens. DCs are professional immunity activators that alert T cells to the presence of invaders by displaying antigens on their surface. This display is ramped u...
متن کاملFRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth.
Focal adhesion kinase (FAK) was first identified as a viral Src (v-Src) substrate, but the role of FAK in Src transformation events remains undefined. We show that stable expression of the FAK C-terminal domain (termed FRNK) in v-Src-transformed NIH 3T3 fibroblasts inhibited cell invasion through Matrigel and blocked experimental metastases in nude mice without effects on cell motility. FRNK in...
متن کاملCarcinoma Metastases Activating Cell Motility and Invasion
Several gene mutations responsible for human cancer initiation have been discovered, whereas only a few have been identified in association with the progression to metastasis. In this study, we screened a large panel of human sporadic cancers, metastases, and tumor cell lines for mutations in the tyrosine kinase domain of the MET receptor, crucially involved in invasive cell growth and motility...
متن کاملReassessing the mechanics of parasite motility and host-cell invasion
507 The Rockefeller University Press $30.00 J. Cell Biol. Vol. 214 No. 5 507–515 www.jcb.org/cgi/doi/10.1083/jcb.201605100 Introduction The ancient phylum Apicomplexa includes many of the world’s preeminent pathogens (Woo et al., 2015), such as Plasmodium, the genus responsible for more than half a million malaria-related deaths each year (White et al., 2014), and Toxoplasma gondii, one of the ...
متن کاملEffect of StarD13 on colorectal cancer proliferation, motility and invasion.
Colon cancer is a cancer of the epithelial cells lining the colon. It is mainly divided into different stages according to the invasiveness and metastatic ability of the tumor. Many mutations are acquired which leads to the development of this malignancy. These occur in entities that greatly affect the cell cycle, cell signaling pathways and cell motility, which all involve the action of Rho GT...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2007
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1797iti2